Using Lessons From Toxic Shock Syndrome to Enhance Breast Cancer Immunotherapy

A histone deacetylase inhibitor, panobinostat, enhances chimeric antigen receptor T-cell antitumor effect against pancreatic cancer

AI Ali, M Wang, B Von Scheidt, PM Dominguez, AJ Harrison, DGM Tantalo, J Kang, AJ Oliver, JD Chan, X Du, Y Bai, B Lee, RW Johnstone, PK Darcy, MH Kershaw, CY Slaney

2021-11-15

Purpose: In this article, we describe a combination chimeric antigen receptor (CAR) T-cell therapy that eradicated the majority of..

Cross-talk between tumors at anatomically distinct sites

AJ Oliver, PK Darcy, JA Trapani, MH Kershaw, CY Slaney

2021-01-01

Cancer tissue is not homogenous, and individual metastases at different anatomical locations can differ from the primary tumor and..

Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells

JD Chan, B von Scheidt, B Zeng, AJ Oliver, AS Davey, AI Ali, R Thomas, JA Trapani, PK Darcy, MH Kershaw, R Dolcetti, CY Slaney

2020-01-01

Objectives: Adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is a form of cancer immunotherapy that has achie..

Enterotoxins can support CAR T cells against solid tumors

B Von Scheidt, M Wang, AJ Oliver, JD Chan, MK Jana, AI Ali, F Clow, JD Fraser, KM Quinn, PK Darcy, MH Kershaw, CY Slaney

2019-12-10

Responses of solid tumors to chimeric antigen receptor (CAR) T cell therapy are often minimal. This is potentially due to a lack o..